Rapamycin
Rapamycin is an FDA-approved immunosuppressant being researched for longevity. It inhibits mTOR, a pathway linked to aging. Currently used off-label by some longevity enthusiasts under medical supervision.
Research Level: Promising but limited human data
Dosage
Varies widely; typically 1-6mg weekly (pulsed dosing). REQUIRES medical supervision.
When to Take
Usually taken weekly, not daily, to minimize immune suppression.
Benefits
- ✓Most robust lifespan extension in animal studies
- ✓Inhibits mTOR pathway
- ✓May improve immune function at low doses
- ✓Potential anti-cancer properties
- ✓May improve metabolic health
How It Works
Rapamycin inhibits mTOR (mechanistic target of rapamycin), a nutrient-sensing pathway. Reduced mTOR signaling mimics caloric restriction and activates autophagy (cellular cleanup), key longevity mechanisms.
Food Sources
Possible Side Effects
- •Immune suppression (dose-dependent)
- •Mouth sores
- •Elevated lipids and blood sugar
- •Impaired wound healing
- •Potential for infections
Drug Interactions
- •Many drug interactions
- •CYP3A4 inhibitors and inducers
- •Other immunosuppressants
- •Grapefruit juice
What to Look For
- →Prescription medication only
- →Requires medical supervision
- →Blood monitoring essential
- →Not a supplement—do not buy online
Medical Disclaimer
This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before starting any supplement, especially if you have existing health conditions or take medications. Supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease.