Fisetin
Fisetin is a flavonoid found in strawberries and other fruits. It's being researched as a powerful senolytic—a compound that clears senescent 'zombie' cells linked to aging and disease.
Research Level: Promising but limited human data
Dosage
100-500mg daily for general use; higher doses (1-2g) intermittently for senolytic effects
When to Take
For senolytic effects, some protocols use high doses for 2-3 consecutive days monthly.
Benefits
- ✓Potent senolytic activity
- ✓Clears damaged senescent cells
- ✓Anti-inflammatory properties
- ✓Neuroprotective effects
- ✓May support memory and cognition
- ✓Antioxidant protection
How It Works
Fisetin selectively induces apoptosis (programmed death) in senescent cells while sparing healthy cells. Senescent cells accumulate with age and secrete inflammatory compounds that damage surrounding tissue.
Food Sources
Possible Side Effects
- •Generally well-tolerated
- •Limited human safety data at high doses
- •Possible GI upset
Drug Interactions
- •May enhance effects of chemotherapy (consult oncologist)
- •Theoretical interaction with blood thinners
What to Look For
- →High-purity fisetin (98%+)
- →Third-party tested
- →Liposomal form for better absorption
Medical Disclaimer
This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before starting any supplement, especially if you have existing health conditions or take medications. Supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease.