Adapalene (Differin)
Adapalene is a third-generation retinoid originally prescription-only, now available OTC as Differin. It's gentler than tretinoin while still being effective for acne and anti-aging.
When to Use
Evening
Concentration
0.1% - 0.3%
Best For
Acne, Sensitive skin, Retinoid beginners, Maintenance
How It Works
Adapalene binds to specific retinoic acid receptors that regulate cell turnover and reduce inflammation. It's more selective than tretinoin, causing less irritation.
Benefits
- ✓Gentler than tretinoin
- ✓Effective for acne
- ✓Available without prescription
- ✓More stable in light and air
- ✓Good starter retinoid
Pairs Well With
- + Hyaluronic Acid
- + Niacinamide
- + Gentle Moisturizer
Avoid Using With
- ✕ Other retinoids
- ✕ Benzoyl Peroxide (same application)
Getting Started
Start with 0.1% every other night. It's gentler than tretinoin but still expect some adjustment. Can use with benzoyl peroxide in separate routines.
Build your routine
Learn how to incorporate Adapalene (Differin) into a complete skincare routine.
Read the Skincare Guide